| Product Name | GDNF Receptor alpha 1 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to GDNF Receptor alpha 1Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRalpha , which is a cell surface receptor for GDNF. The cDNA encoding GDNFRalpha from human, rat, chicken and mouse have been cloned recently. GDNFRalpha was also termed Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRalpha -1 recently. GFRalpha -1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRalpha and the Ret PTK from a complex to transduce GDNF signal and to mediate GDNF function. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| Western blot analysis (0.5-4 μg/ml). However, the optimal conditions should be determined individually. | |
| Species Reactivity | HumanMouseRat |
| Concentration | 0.5mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | GDNF, GFR a, GFRa, GFR-alpha, GFRA1, GFR alpha, GFRalpha, GFR-a, Glial cell line derived neurotrophic factor, GFRalpha1 |
|---|---|
| Target | GDNF Receptor alpha 1 |
| Tissue Specificity | This antibody is specific for GDNF Receptor alpha 1. |
| Application Notes | Western blot analysis (0.5-4 μg/ml). However, the optimal conditions should be determined individually. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | The antibody solution should be gently mixed before use. Stored at -20 °C for future use. |
| Storage Buffer | Phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal. |
