| Product Name | GDNF Receptor alpha 2 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal to GDNF Receptor alpha 2Members of the glial cell line derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN), play key roles in the control of vertebrate neuronal survival and differentiation. Physiological responses to NTN require the presence of a novel glycosyl phosphatidylinositol linked protein, NTNR alpha, which is a cell surface receptor for NTN. The cDNAs encoding NTNR alpha from human, rat, chicken, and mouse have been cloned. GFR alpha 2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFR alpha 2, and the Ret PTK form a complex to transmit the NTN signal and to mediate NTN function. |
| Immunogen | Synthetic peptide: RVEKTPSLPDDLSDS, corresponding to amino acids 377-391 of Human GDNF Receptor alpha 2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB: 1/1000 - 1/2000. Detects a band of approximately 52 kDa (predicted molecular weight: 52 kDa). Optimal dilutions/concentrations should be determined by the end user. | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | NTNRA, 601956, RETL2, GFR alpha2, GFRA2, TRNR2, NRTNR-ALPHA, GDNFRB, GFR alpha 2, NRTNRALPHA, 2675, O00451, NRTNR ALPHA |
|---|---|
| Target | GDNF Receptor alpha 2 |
| Tissue Specificity | This antibody recognizes human, mouse, and rat GDNF Receptor alpha 2. |
| Cellular Localization | Attached to the membrane by a GPI anchor. |
| Positive Control | Whole cell lysate of HeLa cells. |
|---|---|
| Application Notes | WB: 1/1000 - 1/2000. Detects a band of approximately 52 kDa (predicted molecular weight: 52 kDa). Optimal dilutions/concentrations should be determined by the end user. |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Preservative: 0.02% Sodium Azide. Constituents: PBS. pH 7.4 |
