Rabbit polyclonal antibody to GDNF Receptor alpha 2Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Immunogen
Synthetic peptide from C-terminus of human GDNF Receptor alpha 2
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
ICC/IFIHC-FWB
Western Blotting: Max Dilution 1/1000 Optimal dilution / concentration should be determined by the end user.
WB analysis of HeLa cell lysate using GDNF Receptor alpha 2 antibody.
Application Notes
Western Blotting: Max Dilution 1/1000 Optimal dilution / concentration should be determined by the end user.
Additional Information
Form
Liquid
Storage Instructions
Store at +4°C or at -20°C if preferred. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.