Rabbit anti-GIPC polyclonal antibodyGIPC is a PDZ-domain-containing adapter protein. GIPC binds to proteins that have at their C-termini a conserved type I PDZ-binding site (S/T)_X_(V/A). GIPC’s PDZ domain can bind multiple members of the low-density lipoprotein receptor (LDLR) family (e.g megalin), kinase receptors, G-protein coupled receptors and cell-surface adhesion proteins.. GIPC also binds directly to myosin-VI (make this myosin-VI be a link to the other antibody). GIPC is found on uncoated vesicles along with myosin-VI in all cell types examined. There is also evidence for a role for GIPC in trafficking of transmembrane proteins through the Golgi stacks. Other names for GIPC include: synectin, SEMCAP-1, GLUT1CBP.
Immunogen
Rabbits were immunized with amino acids 100-333 from rat GIPC protein.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
ICC/IFIPWB
IF (5-10 ug/ml), IP (1-10 ug/reaction), WB (0.1-0.5 ug/ml):
Species Reactivity
HumanRatPrimate
Concentration
0.5mg/ml
Target Information
Gene Synonyms
GIPC1 Rgs19ip1 Gipc Rgs19 83823
Target
GIPC1
Application Notes
IF (5-10 ug/ml), IP (1-10 ug/reaction), WB (0.1-0.5 ug/ml):
Additional Information
Form
Liquid
Storage Instructions
Store at -20º C. Avoid multiple freeze/thaw cycles.
Storage Buffer
50 ug (0.5 mg/ml) of affinity purified IgG with 50% glycerol, 0.01% sodium azide and 1.0 mg/ml BSA.