Rabbit Polyclonal antibody to GLIS2This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and may have a role in the regulation of kidney morphogenesis. p120 regulates the expression level of this protein and induces the cleavage of this protein's C-terminal zinc finger domain. This protein also promotes the nuclear translocation of p120. Mutations in this gene cause nephronophthisis (NPHP), an autosomal recessive kidney disease characterized by tubular basement membrane disruption, interstitial lymphohistiocytic cell infiltration, and development of cysts at the corticomedullary border of the kidneys.[provided by RefSeq, Jan 2010]
Immunogen
GLIS2 antibody was raised against an 18 amino acid peptide near the center of human GLIS2.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
ELISAIHC-PWB
WB: 1 - 2 ug/ml. IHC-P: 5 ug/ml:
Species Reactivity
HumanMouse
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)
Purification
Affinity purified
Target Information
Gene Synonyms
NPHP7 NKL GLIS family zinc finger 2
Target
GLIS2
Tissue Specificity
GLIS2 antibody is human, mouse and rat reactive.
Application
Application
Immunohistochemistry of GLIS2 in mouse kidney tissue with GLIS2 antibody at 5 ug/ml.
Application
Western blot analysis of GLIS2 in K562 cell lysate with GLIS2 antibody at 1 ug/ml.
Application Notes
WB: 1 - 2 ug/ml. IHC-P: 5 ug/ml:
Additional Information
Form
Liquid
Storage Instructions
GLIS2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Storage Buffer
GLIS2 antibody is supplied in PBS containing 0.02% sodium azide.