| Product Name | Glucocorticoid Receptor antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [8E9] to Glucocorticoid ReceptorThis gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011] |
| Immunogen | 26 amino acid peptide corresponding to residues 150-176 of human GCR linked to human thyroglobulin. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 8E9 |
| Host Species | Mouse |
| Tested Applications | ELISAWB |
| ELISA: Max Dilution 1/1000: |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | GCCR GRL GCR GR NR3C1 nuclear receptor subfamily 3 group C member 1 (glucocorticoid receptor) |
|---|---|
| Target | Glucocorticoid Receptor |
| Tissue Specificity | This antibody recognizes human GR, binding to an epitope between amino acids 167-176 and is therefore expected to bind all described isoforms. |
| Application Notes | ELISA: Max Dilution 1/1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4°C or at -20°C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Storage Buffer | Phosphate buffered saline containing 0.09% Sodium Azide 0.1% Bovine Serum Albumin |
