Rabbit polyclonal antibody to Glucosidase I (mannosyl-oligosaccharide glucosidase )This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Immunogen
Recombinant protein encompassing a sequence within the center region of human Glucosidase I. The exact sequence is proprietary.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WB
*Optimal dilutions/concentrations should be determined by the researcher.
:
Species Reactivity
Human
Predicted Reactivity
MouseMouse (87%)
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)
Purification
Affinity purified
Target Information
Gene Synonyms
CDG2B antibody GCS1 antibody MOGS antibody mannosyl-oligosaccharide glucosidase antibody glucosidase I antibody processing A-glucosidase I antibody
Target
GCS1
Molecular Weight(MW)
92 kDa (note) (2)
Cellular Localization
Endoplasmic reticulum membrane; Single-pass type II membrane protein
Application
Application
Sample(30 ug whole cell lysate) A:H1299 7.5% SDS PAGE diluted at 1:1000