Rabbit monoclonal antibody [EP966Y] to GluR2Glutamate receptor type 2 (GluR2) is one of the four subunits of α-amino-5-hydroxy-3-methyl-4-isoxazole propionic acid (AMPA) receptor. AMPA receptor is a non-NMDA-type ionotropic transmembrane receptor for glutamate that mediates fast synaptic transmission in the central nervous system (CNS . AMPA receptors are composed of four types of subunits, designated as GluR1, GluR2, GluR3, and GluR4 (alternatively called GluRA-D), which combine to form tetramers . The complex comprising of GluR2 and GluR3 is one of the two predominant forms in the adult hippocampus. All four GluRs interact with specific cytoplasmic protein through their C-terminal tails. Although in contrast to GluR1 and GluR4, GluR3 and GluR2 have a short C-terminal tail .
Immunogen
A synthetic peptide corresponding to a residue near N-term of human Glutamate receptor type 2 was used as immunogen.