Application
HC analysis of mouse embryonic brain using GnRH antibody.Application
IHC analysis of Hyla cinerea (green treefrog) forebrain using GnRH antibody at a dilution of 1:1000.| Product Name | GnRH antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to GnRHGonadotropin releasing hormone (GnRH), also known as luteinizing hormone releasing hormone (LHRH), is a key molecule in the regulation of reproduction in vertebrates. GnRH, a decapeptide, is produced by neurons in the medial basal hypothalamus (MBH) and secreted in a pulsatile manner into the cardiovascular system. The frequency and amplitude of GnRH pulses determine secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. Higher frequencies (greater than one pulse per hour) stimulate LH secretion while lower frequencies stimulate FSH secretion. The generation of GnRH pulses is effected by numerous stimuli, such as neural, hormonal and environmental. Therefore, behavioral and physiological conditions such as sleep, exercise, and stress can affect the GnRH pulses and cause a disruption of the normal cycle. ? Recent studies show that GnRH also has a role in mediating cancer. GnRH has been shown to inhibit the growth of human uterine leiomyloma cells by suppressing proliferation and inducing apoptosis. GnRH analogs have been used to treat a wide variety of reproductive cancers, although the side effects of using such compounds are often quite severe. |
| Immunogen | Synthetic peptide corresponding to residues pyroE(22) H W S Y G L R P G-NH2(32) of mouse GnRH. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ICC/IFIHCIHC-P |
| IHC-P: 1:200 - 1:1000: |
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| Species Reactivity | MouseAmphibians |
| Predicted Reactivity | RatRat(100%) |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | Gnrh1 Gnrh Gnrh2 LHRH Lhrh1 Lnrh hpg gonadotropin releasing hormone 1 |
|---|---|
| Target | GnRH |
Application
HC analysis of mouse embryonic brain using GnRH antibody.
Application
IHC analysis of Hyla cinerea (green treefrog) forebrain using GnRH antibody at a dilution of 1:1000.| Application Notes | IHC-P: 1:200 - 1:1000: |
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| Form | Liquid |
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| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS containing 1 mg/ml BSA and 0.05% sodium azide. |
