| Product Name | GSK3 alpha antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to GSK3 alphaGlycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase that has been implicated in the regulation of cell fate and in the Wnt signaling pathway. GSK-3 plays an important role in the PI3 kinase and Akt mediated cell survival pathways, and its activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3alpha and Ser9 of GSK-3beta. GSK-3 has also been implicated in alzheimer’s disease. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK-3. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHCIP |
| Western blot analysis (1-2 μg/ml) and Immunohistochemistry (20-30 μg/ml). However, the optimal conditions should be determined individually. The antibody detects GSK-3 from human, mouse, & rat origin non cross-reactive with GSK-3: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 0.2mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | Glycogen synthase kinase-3 Glycogen synthase kinase3 DKFZp686D0638 GSK3 alpha GSK-3 alpha GSK-3alpha GSK3alpha GSK3a GSK 3alpha GSK 3 alpha Glycogen synthase kinase 3 |
|---|---|
| Target | GSK-3a |
| Tissue Specificity | This antibody is specific for GSK-3a. |
| Application Notes | Western blot analysis (1-2 μg/ml) and Immunohistochemistry (20-30 μg/ml). However, the optimal conditions should be determined individually. The antibody detects GSK-3 from human, mouse, & rat origin non cross-reactive with GSK-3: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | The antibody solution should be gently mixed before use. Stored at -20 °C for future use. |
| Storage Buffer | PBS (pH 7.2) containing 50% glycerol, 1% BSA, 0.02% sodium azide |
