Application
Immunohistochemical analysis of paraffin-embedded human breast intraductal carcinama tissues (A) and breast infiltrating ductal carcinama tissues (B) showing membrane localization using anti-ERBB2 mAb with DAB staining.Application
Western blot analysis using anti ERBB2 mAb against truncated ERBB2 recombinant protein.| Product Name | Her2 / ErbB2 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [6C2B12,9B9D8] to ErbB2This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008] |
| Immunogen | The immunogen corresponding to a region within amino acids 750 and 987 of human ERBB2 expressed in E. Coli. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 6C2B12,9B9D8 |
| Host Species | Mouse |
| Tested Applications | ELISAIHCIHC-PWB |
| ELISA: 1/10000.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | ERBB2 MLN 19 HER-2/NEU TKR1 NEU NGL CD340 HER-2 HER2 |
|---|---|
| Target | ERBB2 |
Application
Immunohistochemical analysis of paraffin-embedded human breast intraductal carcinama tissues (A) and breast infiltrating ductal carcinama tissues (B) showing membrane localization using anti-ERBB2 mAb with DAB staining.
Application
Western blot analysis using anti ERBB2 mAb against truncated ERBB2 recombinant protein.| Application Notes | ELISA: 1/10000.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4℃, for long term storage, store at -20℃. |
| Storage Buffer | Ascitic fluid containing 0.03% sodium azide. |
