Rabbit polyclonal antibody to Histamine H3 ReceptorH3 Histamine Receptor regulates the release of the neurotransmitters norepinephrine and somatostatin. In histamine-containing neurons of the brain, the H3 receptor acts as a presynaptic autoreceptor, while in nonhistamine-containing neurons in both the central and peripheral nervous systems, it acts as a presynaptic heteroreceptor. Multiple isoforms of H3 receptors are produced by alternative splicing. Histamine H3 receptor has been reported primarily in brain. ESTs have been isolated from brain (normal and cancer), breast cancer, colon cancer, and retinoblastoma libraries.
Immunogen
Synthetic peptide [KLH conjugated] made to the 3rd cytoplasmic loop
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
ICC/IFIHC
We recommend the following starting dilutions: immunohistochemistry -F (18-36 ug/ml), Immunocytochemistry . Optimal concentration should be determined experimentally by the end user.:
Species Reactivity
Human
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)
Purification
Affinity purified
Target Information
Gene Synonyms
GPCR97 HH3 R 11255 Histamine receptor H3 G protein coupled receptor 97 G protein coupled receptor97 HH3R Histamine H3 receptor HRH3 HRH 3
Target
Histamine H3 Receptor
Application
Application
Immunohistochemistry: Histamine H3 Receptor Antibody [ - Staing of neuron in brain tissue sections (A), untransfected (B), and histamine H3 receptor-transfected cells (C).
Application Notes
We recommend the following starting dilutions: immunohistochemistry -F (18-36 ug/ml), Immunocytochemistry . Optimal concentration should be determined experimentally by the end user.:
Additional Information
Form
Liquid
Storage Instructions
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.