| Product Name | HMGCR antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to HMG-CoA reductase (3-hydroxy-3-methylglutaryl-Coenzyme A reductase)HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of human HMGCR. The exact sequence is proprietary. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| *Optimal dilutions/concentrations should be determined by the researcher.
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| Species Reactivity | Mouse |
| Predicted Reactivity | Human, Rat, Xenopus laevis, Pig, Chicken, BovineHuman (100%), Rat (93%), Xenopus laevis (85%), Pig (97%), Chicken (89%), Bovine (98%) |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | LDLCQ3 antibody HMGCR antibody hydroxymethylglutaryl-CoA reductase antibody HMG-CoA reductase antibody 3-hydroxy-3-methylglutaryl-Coenzyme A reductase antibody 3-hydroxy-3-methylglutaryl CoA reductase (NADPH) antibody 3-hydroxy-3-methylglutaryl-CoA r |
|---|---|
| Target | HMG-CoA reductase |
| Molecular Weight(MW) | 97 kDa (note) (2) |
| Cellular Localization | Endoplasmic reticulum membrane; Multi-pass membrane protein , Peroxisome membrane; Multi-pass membrane protein |
| Application Notes | *Optimal dilutions/concentrations should be determined by the researcher.
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| Form | Liquid |
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| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
