Mouse monoclonal antibody [F45 P9 C7] to hnRNP KThis gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized. [provided by RefSeq, Jul 2008]
Immunogen
Synthetic peptide, conjugated to Ovalbumin, corresponding to residues S(453) V K Q Y S G K F F(463) of the hnRNP-K protein.
Key Feature
Clonality
Monoclonal
Isotype
IgG1
Clone Number
F45 P9 C7
Host Species
Mouse
Tested Applications
FACSICC/IFIHCWB
ICC/IF: 5 µg/ml:
Species Reactivity
HumanMouseChickenRatRabbit
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)
Purification
Protein G
Target Information
Gene Synonyms
HNRNPK HNRPK CSBP heterogeneous nuclear ribonucleoprotein K TUNP
Target
RNP-K
Application
Application
Immunohistochemistry of RNP-K expression in colon carcinoma.
Application
Western blot of RNP-K in cell lysates. ?
Application Notes
ICC/IF: 5 µg/ml:
Additional Information
Form
Liquid
Storage Instructions
-20° C, Avoid Freeze/Thaw Cycles
Storage Buffer
PBS containing 1 mg/ml BSA and 0.05 % sodium azide