| Product Name | HSD11B2 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to HSD11B2 (hydroxysteroid (11-beta) dehydrogenase 2)There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq] |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human HSD11B2. The exact sequence is proprietary. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC-F |
| *Optimal dilutions/concentrations should be determined by the researcher.
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| Species Reactivity | Sheep |
| Predicted Reactivity | Human, Mouse, Rat, Pig, Rabbit, BovineHuman (100%), Mouse (83%), Rat (85%), Pig (81%), Rabbit (86%), Bovine (81%) |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | AME antibody AME1 antibody HSD11K antibody HSD2 antibody SDR9C3 antibody HSD11B2 antibody 11-beta-hydroxysteroid dehydrogenase type II antibody 11-beta-HSD2 antibody 11-beta-hydroxysteroid dehydrogenase type 2 antibody 11-beta-HSD antibody 11-DH2 |
|---|---|
| Target | HSD11B2 |
| Molecular Weight(MW) | 44 kDa (note) |
| Cellular Localization | Microsome , Endoplasmic reticulum |
| Positive Control | Target recombinant protein |
|---|---|
| Application Notes | *Optimal dilutions/concentrations should be determined by the researcher.
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| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
