| Product Name | Human IgE antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse Monoclonal antibody [4F4] to Human IgEIgE is typically the least abundant isotype - blood serum IgE levels in a normal ("non-atopic") individual are ~150 ng/ml, compared to 10 mg/ml for the IgGs - it is capable of triggering the most powerful immune reactions. Most of our knowledge of IgE has come from research into the mechanism of a form of allergy known as type 1 hypersensitivity.There is much speculation into what physiological benefits IgE contributes, and so far, circumstantial evidence in animal models and statistical population trends have hinted that IgE may be beneficial in fighting gut parasites such as Schistosoma mansoni, but this has not been conclusively proven in humans.IgE may play an important role in the immune system's recognition of cancer, in which the stimulation of a strong cytotoxic response against cells displaying only small amounts of early cancer markers would be beneficial. IgE may be an important target in treatments for allergy and asthma. |
| Immunogen | IgE from myelomatous human serum. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2a |
| Clone Number | 4F4 |
| Host Species | Mouse |
| Tested Applications | ELISA |
| For ELISA: Use at an assay dependent dilution. GTX27294 can be used for the detection of total IgE level and IgE antibodies in ELISA in combination with GTX27295, coating GTX27295 - conjugate GTX27294. Optimal dilutions/concentrations should be determined by the researcher.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Synonyms | IgE |
|---|---|
| Target | Human IgE |
| Tissue Specificity | IgE Ce3-domain specific. |
| Application Notes | For ELISA: Use at an assay dependent dilution. GTX27294 can be used for the detection of total IgE level and IgE antibodies in ELISA in combination with GTX27295, coating GTX27295 - conjugate GTX27294. Optimal dilutions/concentrations should be determined by the researcher.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution, aliquot and store at 4°C. |
| Storage Buffer | Phosphate-buffered saline, pH 7.4, containing 0.1% sodium azide |
