Application
Western blot analysis of IA-1 in rat thymus tissue lysate with IA-1 antibody at 1 ug/ml.| Product Name | IA-1 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to IA-1IA-1, also known as INSM1, is an essential five zinc-finger transcription factor that while initially identified from an insulinoma cDNA library, is expressed in the developing nervous system. Specifically, IA-1 is expressed as early as E9.5 in mice in the fore-, mid- and hindbrain, spinal cord, retina, and olfactory bulb. It is thought that IA-1 functions as a transcriptional repressor, and is a part of several signaling pathways including those of Notch and sonic hedgehog in addition to that of Ngn3 during pancreatic endocrine cell differentiation. IA-1 is also expressed in multiple tumors, including the majority of neuroendocrine tumors tested so far as well as nearly 100% of all small cell lung carcinomas, indicating that IA-1 may be an important target in cancer therapy. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | INSM1 IA1 Insulinomaassociated 1 Insulinoma-associated 1 Insulinomaassociated1 IA-1 IA 1 Insulinoma associated 1 |
|---|---|
| Target | IA-1 |
| Tissue Specificity | This antibody is specific for IA-1 |
Application
Western blot analysis of IA-1 in rat thymus tissue lysate with IA-1 antibody at 1 ug/ml.| Positive Control | Blocking Peptide: Cat.No. GTX85243-PEP - IA-1 Peptide Lysates: Cat. No. GTX24041 - Rat Thymus Tissue Lysate |
|---|---|
| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS containing 0.02% sodium azide |
