| Product description |
Mouse monoclonal [8.4A6] to ICAM1Human CD54, also known as intercellular adhesion molecule 1 (ICAM1), is a 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. It shares considerable amino acid sequence homology with CD50 (ICAM3) and with CD102 (ICAM2). ICAM1 (CD54) is expressed by activated endothelial cells. It is detected on cells of many other lineages (e.g. epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase in inflammation. Also, ICAM1 (CD54) is detected in some carcinoma and melanoma cells. Soluble ICAM1 (CD54) is detectable in the plasma and is elevated in patients with various inflammatory syndromes. ICAM1 (CD54) mediates myeloid cells adhesion to activated vascular endothelium at the vessel wall and to other leucocytes. ICAM1 (CD54) mediates T cell interactions with antigen presenting cells or target cells and also other T-T or T-B cell interactions. It seems to serve as an adhesion receptor for Plasmodium falciparum, thereby enabling binding of infected RBC to the vascular endothelia in selected organs, causing the typical sequestration of severe malaria. ICAM1 (CD54) is the ligand for the integrin LFA1 (CD11a/CD18). In addition, ICAM1 has binding sites for Rhinovirus, Mac1(CD11b/CD18) and Plasmodium falciparuminfected erythrocytes. |
