Rabbit polyclonal antibody to IL15The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]
Immunogen
Recombinant human IL15
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
ELISAIHC-PIPWBFunctional Assay
ELISA: Max Dilution 0.5 ug/ml:
Species Reactivity
Human
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
interleukin 15 IL-15
Target
IL15
Tissue Specificity
This antibody recognizes human IL15 (Interleukin-15)
Application
Application
IHC-P analysis of normal human placenta tissue using IL15 antibody.
Application Notes
ELISA: Max Dilution 0.5 ug/ml:
Additional Information
Form
Liquid
Storage Instructions
Prior to reconstitution store at +4°C. Following reconstitution store at -20°C. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. For long term storage the addition of 0. 09% Sodium Azide is recommended.