| Product Name | IL22 Receptor alpha 1 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal to IL22 Receptor alpha 1A novel cytokine, designated IL-TIF for IL-10 related T cell derived inducible factor and IL-22, was recently identified. The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family. IL-22R forms a complex with IL-10 receptor b chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-a2 (IL-22RA2), was identified very recently. IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response. |
| Immunogen | Synthetic peptide: DSLFRGLALTVQWES, corresponding to amino acids 560-574 of Human IL-22 Receptor alpha 1. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| For WB: Use at a concentration of 0.5 - 1.0 μg/ml. Detects a band of approximately 62 kDa. Optimal dilutions/concentrations should be determined by the researcher.: |
|
| Species Reactivity | Mouse |
| Concentration | 0.5mg/ml |
| Purification | Affinity purified |
| Target | IL22 Receptor alpha 1 |
|---|
| Positive Control | HepG2 whole cell lysate. |
|---|---|
| Application Notes | For WB: Use at a concentration of 0.5 - 1.0 μg/ml. Detects a band of approximately 62 kDa. Optimal dilutions/concentrations should be determined by the researcher.: |
| Form | Liquid |
|---|---|
| Storage Instructions | Upon Receipt - Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | PBS, pH 7.4, with 0.02% sodium azide as preservative. |
