Mouse monoclonal antibody [450-9D] to Integrin beta 4Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Key Feature
Clonality
Monoclonal
Isotype
IgG1
Clone Number
450-9D
Host Species
Mouse
Tested Applications
FACSICC/IFIHC-FIHC-PIPWB
Flow Cytometry: 1/25 - 1/100
:
Species Reactivity
HumanFerretMink(Mustela)
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
ITGB4 CD104
Target
CD104
Tissue Specificity
This antibody recognizes an extracellular epitope on Integrin beta 4.
Application
Application
IHC-Fr analysis of human tonsil tissue using Integrin beta 4 antibody [450-9D] (Azide free).
Application Notes
Flow Cytometry: 1/25 - 1/100
:
Additional Information
Form
Liquid
Storage Instructions
Store at -20°C only. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.