Application
Immunohistochemical analysis of paraffin-embedded MCF7 xenograft, using ITM2C antibody at 1:100 dilution.Application
Sample (30 ug of whole cell lysate) A: Hela 12% SDS PAGE diluted at 1:1000| Product Name | ITM2C antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to ITM2C (integral membrane protein 2C)Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation. |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human ITM2C. The exact sequence is proprietary. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC-PWB |
| *Optimal dilutions/concentrations should be determined by the researcher.
: |
|
| Species Reactivity | Human |
| Predicted Reactivity | Mouse, Rat, Pig, Chicken, Sheep, BovineMouse (95%), Rat (97%), Pig (98%), Chicken (81%), Sheep (97%), Bovine (97%) |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | BRI3 antibody BRICD2C antibody E25 antibody E25C antibody ITM3 antibody ITM2C antibody BRICHOS domain containing 2C antibody integral membrane protein 3 antibody transmembrane protein BRI3 antibody hRPC.1050_D_4 antibody integral membrane protein |
|---|---|
| Molecular Weight(MW) | 30 kDa (note) (5) |
| Cellular Localization | Membrane; Single-pass type II membrane protein |
Application
Immunohistochemical analysis of paraffin-embedded MCF7 xenograft, using ITM2C antibody at 1:100 dilution.
Application
Sample (30 ug of whole cell lysate) A: Hela 12% SDS PAGE diluted at 1:1000| Positive Control | HeLa |
|---|---|
| Application Notes | *Optimal dilutions/concentrations should be determined by the researcher.
: |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
