| Product Name | KIF17 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal to KIF17The kinesin superfamily of proteins (KIFs) consists of a class of microtubule-dependent motors that play a major role in many cellular and developmental functions, including organelle transport, mitosis, meiosis, and possibly long-range signaling in neurons. The kinesin proteins are involved in organelle transport and are primarily associated with anterograde transport of vesicles and organelles in neurons, epithelial cells, and melanosomes with bidirectional transport of mitochondria. They also mediate transport between the endoplasmic reticulum (ER) and the Golgi complex. In neurons, kinesin motors conduct vesicular transport, such as of synaptic vesicle components to axons and of neurotransmitter receptors to dendrites. KIF17 belongs to the functionally diverse subgroup of the kinesin superfamily characterized by a N-terminal motor domain (N-IV class), that includes the KIF3 motor protein. KIF17 is specifically expressed in the brain, present in abundance in the gray matter, particularly in the hippocampus and cerebral cortex, but not in the white matter such as the optic nerve. |
| Immunogen | Synthetic peptide conjugated to KLH, corresponding to amino acids 589-606 of Mouse KIF17. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ICC/IFWB |
| IF: Use at a dilution of 1/100, this is determined using rat pheochromocytoma PC12 cell line differentiated with NGF. WB: Use at a dilution of 1/1000, this concentration is determined using a mouse brain cytosolic fraction. Staining of KIF17 is specifically inhibited with the immunizing peptide. Predicted molecular weight: 170 kDa. Optimal dilutions/concentrations should be determined by the end user. | |
| Species Reactivity | HumanMouseDogRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | 5930435E01Rik, AW492270, Kif17b, mKIAA1405 |
|---|---|
| Target | KIF17 |
| Cellular Localization | Microtubules |
| Application Notes | IF: Use at a dilution of 1/100, this is determined using rat pheochromocytoma PC12 cell line differentiated with NGF. WB: Use at a dilution of 1/1000, this concentration is determined using a mouse brain cytosolic fraction. Staining of KIF17 is specifically inhibited with the immunizing peptide. Predicted molecular weight: 170 kDa. Optimal dilutions/concentrations should be determined by the end user. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Preservative: 15mM Sodium Azide; Constituents: 0.01M PBS. pH 7.4 |
