Rabbit Polyclonal antibody to KPNA6Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family. [provided by RefSeq, Jul 2008]
Immunogen
Recombinant protein of human KPNA6
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHCIHC-PWB
WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Species Reactivity
HumanMouse
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
IPOA7 , KPNA7 , karyopherin subunit alpha 6
Target
KPNA6
Application
Application
Western blot analysis of extracts of various cell lines, using KPNA6 antibody.
Application
Immunohistochemistry of paraffin-embedded human kidney using KPNA6 antibody at dilution of 1:100 (x400 lens).