Application
Western blot analysis of Kv1.3 (pY187) expression in HEK293T EGF-treated (A); SP2/0 EGF-treated (B); PC12 EGF-treated (C) whole cell lysates.| Product Name | Kv1.3 (phospho Tyr187) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to Kv1.3 (phospho Tyr187)Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008] |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Kv1.3. The exact sequence is proprietary. |
| Modification | p-Tyr187 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB: 1:500 - 1:1000: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | HPCN3 HUKIII HLK3 PCN3 potassium channel voltage gated shaker related subfamily A member 3 KV1.3 KCNA3 HGK5 MK3 |
|---|---|
| Target | Kv1.3 (phospho Tyr187) |
| Tissue Specificity | Recognizes endogenous levels of Kv1.3 (pY187) protein. |
Application
Western blot analysis of Kv1.3 (pY187) expression in HEK293T EGF-treated (A); SP2/0 EGF-treated (B); PC12 EGF-treated (C) whole cell lysates.| Application Notes | WB: 1:500 - 1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4 °C. Upon delivery aliquot and store at -20 °C for one year. Avoid freeze/thaw cycles. |
| Storage Buffer | Liquid in 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol; and 0.01% sodium azide. |
