| Product Name | LDL Receptor antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [11A2] to LDL ReceptorThe low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010] |
| Immunogen | Recombinant Human LDL Receptor. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 11A2 |
| Host Species | Mouse |
| Tested Applications | ELISAFACSWB |
| WB(1:500-1000)|ELISA(1:100-2000)|FC(1:10-20): |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | low density lipoprotein receptor LDLR FHC LDLCQ2 FH |
|---|---|
| Target | LDL Receptor |
| Tissue Specificity | This antibody recognizes human LDL Receptor by ELISA and Western Blott. |
| Application Notes | WB(1:500-1000)|ELISA(1:100-2000)|FC(1:10-20): |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS |
