Rabbit polyclonal antibody to LRFN1LRFN1 is one of a family of five transmembrane glycoproteins that are highly expressed in neuronal tissues. LRFN proteins share leucine-rich repeat (LRR)-immunoglobulin-like (Ig)-fibronectin type III (Fn)-transmembrane domain structure with other members of the LRR-Ig-Fn protein superfamily such as the Slitrk family of proteins. Expression of LRFN1, -3, and -4 mRNA was detected in embryonic neuronal cells, while Lrfn2 and Lrfn5 expression was primarily restricted to more mature cells. LRFN1, -2, and -4 bound to PDZ domains of postsynaptic PSD95, re-distributing PSD95 to the cell periphery. It has been suggested that the Lrfn proteins play a role in the developing and/or mature vertebrate nervous system. At least two isoforms of LRFN1 are known to exist. This antibody is predicted to not cross-react with other members of the LRFN family.
Key Feature
Clonality
Polyclonal
Host Species
Rabbit
Tested Applications
ELISAIHC-PWB
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
Leucine-rich repeat and fibronectin typeIII domain-containing protein 1, Leucinerich repeat and fibronectin typeIII domaincontaining protein1, synaptic adhesionlike molecule2, Leucinerich repeat and fibronectin typeIII domaincontaining protein 1, LRFN1, sy
Target
LRFN1
Tissue Specificity
This antibody is specific for LRFN1
Application
Application
Western blot analysis of LRFN1 in human brain lysate with LRFN1 antibody at (A) 1 and (B) 2 ug/ml.
Application
Immunohistochemistry of LRFN1 in mouse brain tissue with LRFN1 antibody at 2.5 ug/ml.
Additional Information
Form
Liquid
Storage Instructions
Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.