| Product Name | LRP6 antibody [EPR2423(2)] |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit monoclonal antibody [EPR2423(2)] to LRP6LRP6 (low-density lipoprotein receptor-related protein 6) is a single span transmembrane Wnt receptor that interacts with Axin to promote the Wnt-dependent accumulation of beta-catenin. Cells treated with Wnt quickly induce plasma membrane-associated LRP6 aggregates. The aggregates are phosphorylated, and then promote Axin recruitment and beta-catenin stabilization. LRP6 is internalized with caveolin and components of this endocytic pathway are required not only for Wnt-3a-induced internalization of LRP6 but also for accumulation of beta-catenin (1-2). |
| Immunogen | It maps within amino acids 1525-1575 of LRP6 of human origin (Swiss Prot: O75581). |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Clone Number | EPR2423(2) |
| Host Species | Rabbit |
| Tested Applications | ICC/IFIHC-FWB |
| For ICC: Use at a dilution of 1:100 - 250 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Unpurified |
| Target | LRP6 |
|---|---|
| Tissue Specificity | is specific for Human LRP6. |
| Cellular Localization | On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmit |
| Application Notes | For ICC: Use at a dilution of 1:100 - 250 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20 °C. Stable for 12 months from date of receipt. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
