Rabbit polyclonal antibody to mAChR M3The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. [provided by RefSeq, Jul 2008]
Immunogen
Synthetic peptide: 3rd cytoplasmic domain of human muscarinic receptor M3, conjugated to Keyhole Limpet Hemocyanin (KLH)
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHC-P
Immunohistology - Paraffin: Max Dilution 10 ug/ml Optimal dilution / concentration should be determined by the end user.
Species Reactivity
Human
Predicted Reactivity
Mouse
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
HM3 , EGBRS , CHRM3
Target
Muscarinic Receptor M3
Tissue Specificity
This antibody detects the muscarinic receptor M3 (mAChR M3).
Application
Application
IHC-P analysis of human brain cortex tissue using mAChR M3 antibody.
Application Notes
Immunohistology - Paraffin: Max Dilution 10 ug/ml Optimal dilution / concentration should be determined by the end user.
Additional Information
Form
Liquid
Storage Instructions
Store at +4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.