Rabbit Polyclonal antibody to MALMAL, a nonglycosylated integral membrane proteolipid, has been identified as a major internal component of glycolipid-enriched membrane (GEM) microdomains. MAL is the first integral membrane proteolipid component to have been shown as a necessary element in the cellular apical sorting apparatus for newly synthesized proteins. In its steady state this highly hydrophobic proteolipid, resides predominantly in the apical zone of polarized epithelial cells. It has also been shown in itinerant protein cycling between the plasma membrane and endosomes and in other cells. This 17-kDa proteolipid contains four putative transmembrane domains. These domains along with its protein trafficking properties are defined by the specific signals delegated by its specific amino acid sequence.
Immunogen
Synthetic peptides corresponding to residues C(114)F D G F T Y (R/K) H Y H E N I(126) of human MAL.
Key Feature
Clonality
Polyclonal
Host Species
Rabbit
Tested Applications
WB
WB: 1:500 Optimal dilution / concentration should be determined by the end user.
Species Reactivity
HumanRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
VIP17, MPV17, Mal Tcell differentiation protein, MALGENE, Mal T-cell differentiation protein, Tcell differentiation protein MAL, Myelin and lymphocyte protein, MAL, T-cell differentiation protein MAL, MAL protein gene
Target
MAL
Application Notes
WB: 1:500 Optimal dilution / concentration should be determined by the end user.
Additional Information
Form
Liquid
Storage Instructions
Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer
PBS containing 1 mg/ml BSA and 0.05% sodium azide.