Application
MC1 Receptor antibody [C2C3], C-term detects MC1R protein at membrane on mouse fore brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse fore brain. MC1 Receptor antibody [C2C3], C-term dilution: 1:500.Application
MC1 Receptor antibody [C2C3], C-term detects MC1R protein at cytosol and membrane on human colon carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded colon carcinoma. MC1 Receptor antibody [C2C3], C-term dilution: 1:500.Application
Sample (30 ug of whole cell lysate) A: Molt-4 10% SDS PAGE diluted at 1:1000| Product Name | MC1 Receptor antibody , C-term |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to MC1 Receptor (melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor))This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq] |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human MC1 Receptor. The exact sequence is proprietary. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC-PWB |
| *Optimal dilutions/concentrations should be determined by the researcher.
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| Species Reactivity | HumanMouse |
| Predicted Reactivity | ChimpanzeeChimpanzee (100%) |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | CMM5 antibody MGC14337 antibody MSH-R antibody SHEP2 antibody MC1R antibody melanocyte-stimulating hormone receptor antibody melanotropin receptor antibody melanocortin receptor 1 antibody MC1-R antibody melanocortin 1 receptor (alpha melanocyte s |
|---|---|
| Target | MC1R |
| Molecular Weight(MW) | 35 kDa (note) |
| Cellular Localization | Cell membrane; Multi-pass membrane protein |
Application
MC1 Receptor antibody [C2C3], C-term detects MC1R protein at membrane on mouse fore brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse fore brain. MC1 Receptor antibody [C2C3], C-term dilution: 1:500.
Application
MC1 Receptor antibody [C2C3], C-term detects MC1R protein at cytosol and membrane on human colon carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded colon carcinoma. MC1 Receptor antibody [C2C3], C-term dilution: 1:500.
Application
Sample (30 ug of whole cell lysate) A: Molt-4 10% SDS PAGE diluted at 1:1000| Positive Control | Molt-4 |
|---|---|
| Application Notes | *Optimal dilutions/concentrations should be determined by the researcher.
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| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
