Application
WB analysis of extracts from various cells using MCM6 antibody.Application
IHC-P analysis of human lung using MCM6 antibody at a dilution of 1:200.Application
IHC-P analysis of rat lung using MCM6 antibody at a dilution of 1:200.Application
ICC/IF analysis of U2OS cells using MCM6 antibody (red) and DAPI (blue).| Product Name | MCM6 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to MCM6The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood. [provided by RefSeq, May 2012] |
| Immunogen | Recombinant protein of human MCM6 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ICC/IFIHC-PWB |
| WB: 1:500 - 1:2000. IHC: 1:50 - 1:200. IF: 1:50 - 1:200: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | Mis5 minichromosome maintenance complex component 6 P105MCM MCG40308 |
|---|---|
| Target | MCM6 |
| Molecular Weight(MW) | 93 kDa (note) |
Application
WB analysis of extracts from various cells using MCM6 antibody.
Application
IHC-P analysis of human lung using MCM6 antibody at a dilution of 1:200.
Application
IHC-P analysis of rat lung using MCM6 antibody at a dilution of 1:200.
Application
ICC/IF analysis of U2OS cells using MCM6 antibody (red) and DAPI (blue).| Application Notes | WB: 1:500 - 1:2000. IHC: 1:50 - 1:200. IF: 1:50 - 1:200: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20°C (regular) or -80°C (long term). Avoid freeze / thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
