| Product Name | Methionine Aminopeptidase 2 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal to Methionine Aminopeptidase 2MetAP-2 is highly conserved across species. The catalytic domains of S. Cerevisiae and human MetAP-2 proteins are ~80% homologous. The function of MetAP-2 remains to be determined. MetAP-2 has been identified, purified and cloned from rat cells as a 67kD eIF-2-associated (elongation inhibitory factor-2) protein, suggesting a possible role in protein translation. Experiments suggest MetAP-2 may be involved in angiogenesis, the process of new blood vessel formation. MetAP-2 binds to the potent anti-angiogenic agent fumagillin. The fungal derived fumagillin, and its more potent metabolite TNP-470, are effective at limiting both the size and metastasis of solid tumors. In view of the identification of MetAP-2 as a fumagillin binding protein, future studies with MetAP-2 should provide important new insights into the mechanisms of fumagillin/TNP- 470 induced cell-cycle arrest and the role of MetAP-2 in angiogenesis. |
| Immunogen | Synthetic peptide selected from the N-terminal region of human METAP2 (KLH). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| For ELISA: Use at a dilution of 1:1,000. For WB: Use at an assay dependent dilution. Predicted molecular weight: 53 kDa. Optimal dilutions/concentrations should be determined by the end user. | |
| Species Reactivity | Human |
| Concentration | 0.2mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | EIF-2-associated p67, METAP2, MNPEP, p67 |
|---|---|
| Target | Methionine Aminopeptidase 2 |
| Application Notes | For ELISA: Use at a dilution of 1:1,000. For WB: Use at an assay dependent dilution. Predicted molecular weight: 53 kDa. Optimal dilutions/concentrations should be determined by the end user. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Upon Receipt - Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | PBS, pH7.2 containing 0.09% sodium azide |
