Application
WB analysis of (1) mouse brain lysates and (2) mouse embryo lysates using GRM1 antibody at a dilution of 1:200.Application
IHC-P analysis of rat brain tissue using GRM1 antibody at a dilution of 1:200.Application
IHC-P analysis of human lung carcinoma tissue using GRM1 antibody at a dilution of 1:200.| Product Name | mGluR1 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to GRM1L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol- |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIHC-PWB |
| P-ELISA:1:500-1000, WB:1:100-500, IHC-P:1:100-500 (based on 0.5 mg/ml): |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 0.5mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | MGLUR1A GRM1A glutamate receptor metabotropic 1 SCAR13 mGlu1 MGLUR1 GPRC1A |
|---|---|
| Target | GRM1 |
Application
WB analysis of (1) mouse brain lysates and (2) mouse embryo lysates using GRM1 antibody at a dilution of 1:200.
Application
IHC-P analysis of rat brain tissue using GRM1 antibody at a dilution of 1:200.
Application
IHC-P analysis of human lung carcinoma tissue using GRM1 antibody at a dilution of 1:200.| Application Notes | P-ELISA:1:500-1000, WB:1:100-500, IHC-P:1:100-500 (based on 0.5 mg/ml): |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles. |
| Storage Buffer | 10 mM PBS, pH 7.4 with 10 mg/ml BSA and 0.1% sodium azide |
