Rabbit polyclonal to MIP 1alphaMIP-1a (macrophage inflammatory protein-1 a) is a 69 amino acid CC chemokine with a molecular weight of 7.9 kDa. MIP-1a induces migration of monocytes/macropages, B lymphocytes, activated CD8+ T cells, natural killer (NK) cells, eosinophils 3,4. MIP-1a also stimulates basophils to release histamine, induces ICAM-1 expression, mast cell degranulation, and production of TNFa, IL-1 and IL-6. In addition to its proinflammatory activities, MIP-1a inhibits the proliferation of hematopoietic stem cells in vitro and in vivo.
Immunogen
Recombinant fragment - amino acids 1-69 of mature rat MIP-1a
Key Feature
Clonality
Polyclonal
Host Species
Rabbit
Tested Applications
IPWB
For WB: Use at a dilution of 1:1,500 - 1:2,500. For IP: Use at a dilution of 1:400 - 1:600. Optimal dilutions/concentrations should be determined by the researcher.:
Species Reactivity
MouseRat
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)
Purification
Affinity purified
Target Information
Gene Synonyms
Mip1-b Scya4 Mip1 b Mip1b
Target
MIP1 alpha
Application
Application
Rat MIP-1 alpha detected by Western blot in RAW264.7 cells treated with LPS (15 hr). 1. Lysate 2. Supernatant
Application Notes
For WB: Use at a dilution of 1:1,500 - 1:2,500. For IP: Use at a dilution of 1:400 - 1:600. Optimal dilutions/concentrations should be determined by the researcher.:
Additional Information
Form
Liquid
Storage Instructions
Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.