| Product Name | MMP12 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [7G20] to MMP-12Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008] |
| Immunogen | human recombinant MMP-12 |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2 |
| Clone Number | 7G20 |
| Host Species | Mouse |
| Tested Applications | IHCWB |
| Western blotting(1:500-2000)|Immunohistochemistry(1:50-300): |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | MME MMP12 matrix metallopeptidase 12 (macrophage elastase) ME HME |
|---|---|
| Target | MMP-12 |
| Tissue Specificity | This antibody recognizes human MMP-12 in western blot without cross reactivity with other human MMPs. |
| Application Notes | Western blotting(1:500-2000)|Immunohistochemistry(1:50-300): |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS |
