| Product Name | MMP13 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [12E10] to MMP-13Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008] |
| Immunogen | human recombinant MMP-13 |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 12E10 |
| Host Species | Mouse |
| Tested Applications | IHCWB |
| Western blotting(1:500-2000)|Immunohistochemistry(1:50-200): |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | matrix metallopeptidase 13 (collagenase 3) MMP13 CLG3 MANDP1 |
|---|---|
| Target | MMP-13 |
| Tissue Specificity | This antibody recognizes human MMP-13 in western blot without cross reactivity with other human MMPs. |
| Application Notes | Western blotting(1:500-2000)|Immunohistochemistry(1:50-200): |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS |
