Application
Detection of MMP-2 in formalin-fixed paraffin-embedded human ovary tissue using anti-MMP2 antibody .Application
Western Blot: MMP2 Antibody (8B4) Western blot analysis of MMP2 expression in ProMMP2 (Lane 1), Active MMP2 (Lane 2) and human pressure ulcer biopsy (Lane 3).| Product Name | MMP2 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [MMP2 / 8B4] to human MMP2Loss of negative growth regulation and high invasive potential are neoplastic traits often associated with abnormal expression of matrix matalloproteinases. MMP-2, the signalling mechanism for cells to begin migration, triggers the movement when it splits laminin-5 and exposes and integrin-binding site on this component of epithelial basement membrane. The changed form of laminin was found in tumors and in tissues being altered. The activated form of MMP2, however, is not found in benign tumors. Thus detection of the enzyme is a possible early indicator of tumor activity. |
| Immunogen | Activated recombinant human MMP-2 |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | MMP2/8B4 |
| Host Species | Mouse |
| Tested Applications | ELISAICC/IFIHC-FIHC-PIPWB |
| ELISA: Use at a concentration of IHC-Fr: Use at a concentration of 2 µg/mL: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | TBE-1 MMP2 CLG4A P08253 CLG4 120360 MMPII 4313 MMP-II MONA TBE1 TBE 1 MMP II |
|---|---|
| Target | MMP2 |
| Tissue Specificity | Pro and active MMP-2 |
| Light Chain Type | kappa |
Application
Detection of MMP-2 in formalin-fixed paraffin-embedded human ovary tissue using anti-MMP2 antibody .
Application
Western Blot: MMP2 Antibody (8B4) Western blot analysis of MMP2 expression in ProMMP2 (Lane 1), Active MMP2 (Lane 2) and human pressure ulcer biopsy (Lane 3).| Positive Control | Lung, nerve, and various tumors |
|---|---|
| Application Notes | ELISA: Use at a concentration of IHC-Fr: Use at a concentration of 2 µg/mL: |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Phosphate-buffered saline containing 0.05% sodium azide |
