| Product Name | MMP-25 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [2B5] to MMP-25Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred |
| Immunogen | human recombinant MMP-25 |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 2B5 |
| Host Species | Mouse |
| Tested Applications | IHCWB |
| Western blotting(1:1000-2000)|Immunohistochemistry(1:50-500): |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | MT-MMP 6 MMP20A MMPL1 MMP20 MMP25 MT6-MMP MT-MMP6 matrix metallopeptidase 25 MTMMP6 MT6MMP |
|---|---|
| Target | MMP-25 |
| Tissue Specificity | This antibody recognizes human MMP-25 in western blot. Reactivity to MMP-25 of other species is not tested. |
| Application Notes | Western blotting(1:1000-2000)|Immunohistochemistry(1:50-500): |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS |
