Rabbit monoclonal antibody [EP1252Y] to MMP-8The matrix metalloproteinases (MMPs) are a family of closely related proteolytic enzymes which are involved in the degradation of different components of the extracellular matrix. There is increasing evidence to indicate that individual MMPs have an important role in tumor invasion and tumour spread . Matrix Metalloporteinase 8 (MMP-8, Collagenase-2, Neutrophil Collagenase) functions mainly to degrade fibrillar type I, II, and III collagens, serpins, and aggrecan. MMP-8 degrades by cleaving at one specific on the fibrillar collagens with higher cleave activity on type I compared to type III collagens. MMP-8 is expressed in neutrophils, chondrocytes, and gingival fibroblasts .
Immunogen
It is raised against a short peptide, which maps between amino acids 160~190 of human MMP-8 (Uniprot:P22894).
Key Feature
Clonality
Monoclonal
Isotype
IgG
Clone Number
EP1252Y
Host Species
Rabbit
Tested Applications
FACSICC/IFIHC-PIPWB
For WB: Use at a dilution of 1:2000:
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Target Information
Gene Synonyms
MMP8 PMNL-CL MMP-8 HNC CLG1 PMNLCL MMP 8 PMNL CL
Target
MMP-8
Molecular Weight(MW)
72 (note)
Application
Application
B. Immunohistochemical analysis of paraffin-embedded human placenta using anti-MMP8 RabMAb (Cat# ).
Application
A. Western blot analysis on rat lung using anti-MMP8 RabMAb (cat. # ) dilution 1:2000.
Application Notes
For WB: Use at a dilution of 1:2000:
Additional Information
Form
Liquid
Storage Instructions
Store at -20 °C. Stable for 12 months from date of receipt.
Storage Buffer
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.