Application
Immunohistochemical analysis of paraffin-embedded BT483 xenograft, using MRP1 antibody at 1:250 dilution.Application
Sample (30 µg of whole cell lysate) A: A431 5% SDS PAGE diluted at 1:1000 The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.| Product Name | MRP1 antibody , N-term |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to MRP1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 1)The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms. [provided by RefSeq] |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human MRP1. The exact sequence is proprietary. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC-PWB |
| *Optimal dilutions/concentrations should be determined by the researcher. | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | ABC29 antibody, ABCC antibody, DKFZp686N04233 antibody, DKFZp781G125 antibody, GS-X antibody, MRP antibody, MRP1 antibody, ABCC1 antibody, leukotriene C(4) transporter antibody, LTC4 transporter antibody, multidrug resistance-associated protein 1 antibody, |
|---|---|
| Molecular Weight(MW) | 172 kDa (note) (5) |
| Cellular Localization | Cell membrane; Multi-pass membrane protein |
Application
Immunohistochemical analysis of paraffin-embedded BT483 xenograft, using MRP1 antibody at 1:250 dilution.
Application
Sample (30 µg of whole cell lysate) A: A431 5% SDS PAGE diluted at 1:1000 The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.| Positive Control | A431 |
|---|---|
| Application Notes | *Optimal dilutions/concentrations should be determined by the researcher. |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
