Rabbit polyclonal antibody to MST-1/Krs-2MST-1 (Mammalian STE20-like kinase 1) is a serine/threonine kinase that has been implicated to play a role in chromatin condensation. Its C-terminal contains nuclear export signals which are released upon caspase mediated cleavage. The N-terminus portion of MST-1 then translocates to the nucleus and will promote chromatin condensation. The full length of MST-1 is localized to the cytoplasm.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WB
Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. Jurkat cell lysate can be used as a positive control. The antibody recognizes MST-1/Krs-2 at 50-60 kDa in samples from human, mouse and rat origins. Reactivity to other species has not been tested.:
Species Reactivity
HumanMouseRat
Concentration
0.2mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
DKFZp686A2068 MST-1 MST1 KRS2 STK4 YSK3 MST 1
Target
MST-1/Krs-2
Tissue Specificity
This antibody is specific for MST-1/Krs-2.
Cellular Localization
The caspase-cleaved form cycles between the nucleus and cytoplasm.
Application
Application
Western blot analysis of MST-1/KRS-2 expression in Jurkat cell lysate.
Application Notes
Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. Jurkat cell lysate can be used as a positive control. The antibody recognizes MST-1/Krs-2 at 50-60 kDa in samples from human, mouse and rat origins. Reactivity to other species has not been tested.:
Additional Information
Form
Liquid
Storage Instructions
The antibody solution should be gently mixed before use. Stored at -20 °C for future use.