Application
Western blot analysis of NALP5 in mouse brain tissue lysate with NALP5 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.Application
Immunofluorescence of NALP5 in human brain tissue with NALP5 antibody at 20 μg/mL.Application
Immunohistochemistry of NALP5 in human brain tissue with NALP5 antibody at 10 μg/mL.| Product Name | NALP5 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to NALP5NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP5, also known as MATER, is a maternal gene required for early embryonic development in mice. Increased NALP5 expression was observed in two neuronal injury models, and transient expression of recombinant NALP5 in neurons induced caspase-3 activation and apoptosis, suggesting that NALP5 also plays a role in caspase activation and apoptosis in injured neurons, and may thus represent a novel target for therapeutic treatment in neurodegenerative disorders. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAICC/IFIHC-PWB |
| ICC/IF:1:200~1:500 IHC-P:1:50~1:200 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | PYPAF8 NLRP5 PAN11 CLR19.8 PYRIN-containing APAF1-like protein 8 PYRINcontaining APAF1like protein 8 PYRINcontaining APAF1like protein8 NALP5 MATER NLR family pyrin domain containing 5 NLR family pyrin domain containing5 |
|---|---|
| Target | NALP5 |
| Tissue Specificity | This antibody is specific for NALP5 |
Application
Western blot analysis of NALP5 in mouse brain tissue lysate with NALP5 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.
Application
Immunofluorescence of NALP5 in human brain tissue with NALP5 antibody at 20 μg/mL.
Application
Immunohistochemistry of NALP5 in human brain tissue with NALP5 antibody at 10 μg/mL.| Positive Control | Blocking Peptide: |
|---|---|
| Application Notes | ICC/IF:1:200~1:500 IHC-P:1:50~1:200 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS containing 0.02% sodium azide |
