| Product Name | Necdin antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal to NecdinBrain specific growth suppressor that facilitates entry into cell cycle arrest. Expressed at high levels during embryonic and neonatal periods. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins. Necdin also interacts with p53 and works in to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences. |
| Immunogen | Fusion protein, corresponding to N terminal amino acids 1-143 of Human Necdin. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB: Use at a concentration of 1 μg/ml. Detects a band of approximately 38 kDa (predicted molecular weight: 36 kDa). Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Protein A |
| Gene Synonyms | 176270 NDN Q99608 HsT16328 Necdin 4692 |
|---|---|
| Target | Necdin |
| Cellular Localization | Nuclear |
| Positive Control | Jurkat lysate. |
|---|---|
| Application Notes | WB: Use at a concentration of 1 μg/ml. Detects a band of approximately 38 kDa (predicted molecular weight: 36 kDa). Optimal dilutions/concentrations should be determined by the end user.: |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Preservative: 0.05% Sodium Azide. Constituents: 30% Glycerol, 0.15M Sodium chloride, 0.1M Tris glycine. pH 7.4 |
