Rabbit Polyclonal antibody to NEIL2NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226])[supplied by OMIM, Mar 2008]
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human NEIL2. The exact sequence is proprietary.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WB
WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher.
Species Reactivity
HumanMonkeyRatBovine
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
NEI2 nei like DNA glycosylase 2 NEH2
Target
NEIL2
Tissue Specificity
Recognizes endogenous levels of NEIL2 protein.
Application
Application
Western blot analysis of NEIL2 expression in HEK293T (A); PC12 (B) whole cell lysates.
Application Notes
WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher.
Additional Information
Form
Liquid
Storage Instructions
Shipped at 4 C. Upon delivery aliquot and store at -20 C for one year. Avoid freeze/thaw cycles.
Storage Buffer
Liquid in 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol; and 0.01% sodium azide.