Rabbit polyclonal antibody to NIPSNAPNIPSNAP is a member of an evolutionarily well conserved gene family and has a strong sequence similarity to the central portion of a protein encoded by C. elegans chromosome III between a 4-nitrophenylphosphatase (NIP) domain and non-neuronal SNAP25-like protein. Recent studies have indicated that NIPSNAP is involved in the regulation of the Ca2+-selective transient receptor potential vanilloid channel 6 (TRPV6). NIPSNAP1 associates with TRPV6 at the plasma membrane and inhibits TRPV6 currents. Other studies show that NIPSNAP’s expression is reduced in the phenylketonuria (PKU) mouse brain, suggesting that NIPSNAP may play a role in memory.
Key Feature
Clonality
Polyclonal
Host Species
Rabbit
Tested Applications
ELISAIHC-PWB
IHC-P:1:50~1:200 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher.
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
Nonneuronal SNAP25like protein NIPSNAP1 NIPSNAP Non-neuronal SNAP25-like protein
Target
NIPSNAP
Tissue Specificity
This antibody is specific for NIPSNAP Internal
Application
Application
Immunohistochemical staining of human brain tissue using Nipsnap antibody at 2.5 ug/ml.
Application
Western blot analysis of NIPSNAP in human brain tissue lysate with NIPSNAP antibody at (A) 0.5 and (B) 1 ug/ml.