Application
Western blot analysis of gp91 phox expression in HepG2 (A); Caco2 (B); MCF7 (C) whole cell lysates.| Product Name | NOX2 / gp91-phox antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to NOX2 / gp91-phoxCytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008] |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human gp91 phox. The exact sequence is proprietary. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| Species Reactivity | HumanMousePigRatRabbitSheep |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | NOX2 , CGD , cytochrome b-245, beta polypeptide , p91PHOX , GP911 , GP91PHOX , AMCBX2 , CYBB |
|---|---|
| Target | NOX2 / gp91-phox |
| Tissue Specificity | Recognizes endogenous levels of gp91 phox protein. |
Application
Western blot analysis of gp91 phox expression in HepG2 (A); Caco2 (B); MCF7 (C) whole cell lysates.| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4 C. Upon delivery aliquot and store at -20 C for one year. Avoid freeze/thaw cycles. |
| Storage Buffer | Liquid in 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol; and 0.01% sodium azide. |
