Application
NUMBL antibody [N1], N-term detects Numb-R protein at cytoplasm on human placenta by immunohistochemical analysis. Sample: Paraffin-embedded placenta. NUMBL antibody [N1], N-term dilution: 1:100.Application
NUMBL antibody [N1], N-term detects NUMBL protein at cytoplasm in rat testis by immunohistochemical analysis. Sample: Paraffin-embedded rat testis. NUMBL antibody [N1], N-term diluted at 1:500.Application
Whole cell extract (30 μg) was separated by 7.5% SDS-PAGE, and the membrane was blotted with NUMBL antibody [N1], N-term diluted at 1:500. The signal was developed with Trident ECL plus-Enhanced.| Product Name | NUMBL antibody , N-term |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to Numb-R (numb homolog (Drosophila)-like)Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human NUMBL. The exact sequence is proprietary. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC-PWB |
| *Optimal dilutions/concentrations should be determined by the researcher.
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| Species Reactivity | HumanRat |
| Predicted Reactivity | Mouse, Rat, BovineMouse (93%), Rat (93%), Bovine (86%) |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | CAG3A antibody CTG3a antibody NBL antibody NUMB-R antibody NUMBLIKE antibody NUMBR antibody TNRC23 antibody NUMBL antibody numb-like protein antibody numb-related protein antibody numb homolog-like antibody numb homolog (Drosophila)-like antibod |
|---|---|
| Target | Numb-R |
| Molecular Weight(MW) | 65 kDa (note) |
| Cellular Localization | Cytoplasm |
Application
NUMBL antibody [N1], N-term detects Numb-R protein at cytoplasm on human placenta by immunohistochemical analysis. Sample: Paraffin-embedded placenta. NUMBL antibody [N1], N-term dilution: 1:100.
Application
NUMBL antibody [N1], N-term detects NUMBL protein at cytoplasm in rat testis by immunohistochemical analysis. Sample: Paraffin-embedded rat testis. NUMBL antibody [N1], N-term diluted at 1:500.
Application
Whole cell extract (30 μg) was separated by 7.5% SDS-PAGE, and the membrane was blotted with NUMBL antibody [N1], N-term diluted at 1:500. The signal was developed with Trident ECL plus-Enhanced.| Positive Control | HepG2 |
|---|---|
| Application Notes | *Optimal dilutions/concentrations should be determined by the researcher.
: |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 1XPBS, 40% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
