| Product Name | p15 INK4b antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [DCS-114.1] to p15 INK4bThis gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008] |
| Immunogen | Full length recombinant p15 INK4b |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | DCS-114.1 |
| Host Species | Mouse |
| Tested Applications | IHCIHC-FIPWB |
| IHC:1:50~1:200 IHC-F:1:50~1:100 IP:1:100~1:500 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | TP15 INK4B P15INK4B P15 MTS2 CDK4I CDKN2B |
|---|---|
| Target | p15 |
| Tissue Specificity | This antibody recognizes human p15 INK4b. |
| Application Notes | IHC:1:50~1:200 IHC-F:1:50~1:100 IP:1:100~1:500 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4°C or at -20°C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Storage Buffer | Phosphate buffered saline containing 0.08% Sodium Azide |
