| Product Name | p38 MAPK antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to p38 MAPKp38 is a 38 kDa Stress Activated Protein Kinase / Map Kinase (SAPK / MAPK) that is fully activated by dual phosphorylation on threonine 180 and tyrosine 182, within the activation loop. p38 MAPK plays a critical role in the initiation of G2 delay after ultraviolet radiation; gene knock-out studies have also revealed a critical role for p38 in cardiac remodeling. Downstream targets of p38 include the transcription factors ELK1 and ATF2 and the kinases MAPKAPK2 and MAPKAPK5. p38 MAPK plays a role in the production of IL-6 and is thought to stabilize erythropoietin production during hypoxic stress. It is activated by environmental stress, many pro-inflammatory cytokines and lipopolysaccharide. Dual phosphorylation by MAP2K3 and MAP2K6 is required for activation of p38 MAPK. It interacts with MAX, Cdc25B, Cdc25C and binds to the kinase interaction domain in the protein tyrosine phosphatase PTPRR; this interaction retains p38 MAPK in the cytoplasm. |
| Immunogen | Synthetic peptide: TYDEVISFVPPPLDQEEMES, corresponding to amino acids 341-360 of Human p38. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IPWB |
| For IP: Use at a concentration of 10 µg/ml. For WB: Use at a concentration of 2µg/ml. Predicted molecular weight: 43 kDa. Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | HumanMouseDogMonkeyPigRatGuinea PigHamsterRabbitSheepBovine |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | CSAID Binding Protein 1 antibody CSAID binding protein antibody CSBP 1 antibody CSBP 2 antibody CSBP antibody CSBP1 antibody CSBP2 antibody CSPB 1 antibody CSPB1 antibody Cytokine suppressive anti inflammatory drug binding protein antibody EXIP antibody MA |
|---|---|
| Target | p38 MAPK |
| Tissue Specificity | Detects a 43 kDa protein |
| Cellular Localization | Cytoplasmic and Nuclear |
| Positive Control | HeLa cell lysate - GTX30595 |
|---|---|
| Application Notes | For IP: Use at a concentration of 10 µg/ml. For WB: Use at a concentration of 2µg/ml. Predicted molecular weight: 43 kDa. Optimal dilutions/concentrations should be determined by the end user.: |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Phosphate-buffered saline, pH 7.2, containing no preservatives |
